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Bile acid receptor and liver regeneration
(2015)
Abstract
 Liver is one of the few organs that can regenerate
itself in response to partial ablation or liver
injury. Liver regeneration has been widely studied
as a paradigm for regenerative organ
regrowth since the introduction of a rodent partial
hepatectomy (PHx) model in 1931 [1 ]. Unlike
a typically anatomic regeneration, regeneration
of the liver is a compensatory hyperplasia of
the remaining tissues and is driven by the functional
deficit of the organism. Liver regeneration
consists of several well-orchestrated phases,
with rapid induction of proliferating factors activating
the quiescent hepatocytes and priming
their subsequent progression through the cell
cycles, followed by re-establishment of original
liver size and renewed quiescence [2–4 ]. Growth
factors and cytokines are the important early
signals to induce the expression of downstream
target genes via activation of several key  transcription factors [5 ]. In addition to growth
factors and cytokines, metabolic signals are considered
as the third major signals during liver
regeneration, which is relatively less studied
[6 ]. Recently, bile acids (BAs) and their receptors
were identified as key metabolic signaling pathway
during liver regeneration and their roles in
promoting liver regeneration have received
more and more attention [7 ,4 ]. In this review,
the roles of BA signaling and BA receptors in
liver regeneration will be summarized and
discussed.
Disciplines
Publication Date
2015
Citation Information
Bile acid receptor and liver regeneration. (2015)
Available at: http://works.bepress.com/zhipeng-meng/5/