The understanding of solvation is an essential prerequisite for the quantitative description and analysis of biomolecular systems because solvation is an elementary process in nature and is of paramount importance to many biomolecular processes. Robust models of polar and nonpolar interactions are vital to understanding the solvation properties of biomolecules and the effects of solvation upon biomolecular folding, binding, enzyme catalysis, and dynamic. Multiscale models of solvation have been used to treat different regions of the molecular systems. In this session, invited speakers will present a wide range of multiscale simulation methodologies in hybrid models of solvation.