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Early Detection of Disease using Electronic Health Records and Fisher's Wishart Discriminant Analysis
Procedia Computer Science
  • Sijia Yang
  • Jian Bian
  • Zeyi Sun, Missouri University of Science and Technology
  • Licheng Wang
  • Haojin Zhu
  • Haoyi Xiong, Missouri University of Science and Technology
  • Yu Li

Linear Discriminant Analysis (LDA) is a simple and effective technique for pattern classification, while it is also widely-used for early detection of diseases using Electronic Health Records (EHR) data. However, the performance of LDA for EHR data classification is frequently affected by two main factors: ill-posed estimation of LDA parameters (e.g., covariance matrix), and "linear inseparability" of the EHR data for classification. To handle these two issues, in this paper, we propose a novel classifier FWDA -- Fisher's Wishart Discriminant Analysis, which is developed as a faster and robust nonlinear classifier. Specifically, FWDA first surrogates the distribution of "potential" inverse covariance matrix estimates using a Wishart distribution estimated from the training data. Then, FWDA samples a group of inverse covariance matrices from the Wishart distribution, predicts using LDA classifiers based on the sampled inverse covariance matrices, and "weighted-averages" the prediction results via Bayesian Voting scheme. The weights for voting are optimally updated to adapt each new input data, so as to enable the nonlinear classification.

Meeting Name
Complex Adaptive Systems Conference with Theme: Cyber Physical Systems and Deep Learning, CAS 2018 (2018: Nov. 5-7, Chicago, IL)
Engineering Management and Systems Engineering
Second Department
Computer Science
Keywords and Phrases
  • Early Detection,
  • Electronic Health Records,
  • Fisher's Wishart Discriminant Analysis,
  • Linear Discriminant Analysis
Document Type
Article - Conference proceedings
Document Version
Final Version
File Type
© 2019 The Authors, All rights reserved.
Creative Commons Licensing
Creative Commons Attribution-Noncommercial-No Derivative Works 4.0
Publication Date
Citation Information
Sijia Yang, Jian Bian, Zeyi Sun, Licheng Wang, et al.. "Early Detection of Disease using Electronic Health Records and Fisher's Wishart Discriminant Analysis" Procedia Computer Science Vol. 140 (2018) p. 393 - 402 ISSN: 1877-0509
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