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Comparison of multiple obesity indices for cardiovascular disease risk classification in South Asian adults: The CARRS Study.
PLoS One
  • Shivani A. Patel, Emory University, Atlanta, Georgia, United States of America
  • Mohan Deepa, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
  • Roopa Shivashankar, Centre for Control of Chronic Conditions, Gurgaon, Haryana, India
  • Mohammed K. Ali, Emory University, Atlanta, Georgia, United States of America
  • Deksha Kapoor, All India Institute of Medical Sciences, New Delhi, India
  • Ruby Gupta, Centre for Control of Chronic Conditions, Gurgaon, Haryana, India
  • Dorothy Lall, Institute of Public Health Bengaluru, Bengaluru, Karnataka, India
  • Nikhil Tandon, Centre for Control of Chronic Conditions, Gurgaon, Haryana, India
  • Viswanathan Mohan, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
  • Muhammad Masood Kadir, Aga Khan Unviversity
  • Zafar Fatmi, Aga Khan University
  • Dorairaj Prabhakaran, Centre for Control of Chronic Conditions, Gurgaon, Haryana, India
  • K. M. Venkat Narayan, Emory University, Atlanta, Georgia, United States of America
Publication Date
4-1-2017
Document Type
Article
Disciplines
Abstract

BACKGROUND:

We comparatively assessed the performance of six simple obesity indices to identify adults with cardiovascular disease (CVD) risk factors in a diverse and contemporary South Asian population. METHODS:

8,892 participants aged 20-60 years in 2010-2011 were analyzed. Six obesity indices were examined: body mass index (BMI), waist circumference (WC), waist-height ratio (WHtR), waist-hip ratio (WHR), log of the sum of triceps and subscapular skin fold thickness (LTS), and percent body fat derived from bioelectric impedance analysis (BIA). We estimated models with obesity indices specified as deciles and as continuous linear variables to predict prevalent hypertension, diabetes, and high cholesterol and report associations (prevalence ratios, PRs), discrimination (area-under-the-curve, AUCs), and calibration (index χ2). We also examined a composite unhealthy cardiovascular profile score summarizing glucose, lipids, and blood pressure. RESULTS:

No single obesity index consistently performed statistically significantly better than the others across the outcome models. Based on point estimates, WHtR trended towards best performance in classifying diabetes (PR = 1.58 [1.45-1.72], AUC = 0.77, men; PR = 1.59 [1.47-1.71], AUC = 0.80, women) and hypertension (PR = 1.34 [1.26,1.42], AUC = 0.70, men; PR = 1.41 [1.33,1.50], AUC = 0.78, women). WC (mean difference = 0.24 SD [0.21-0.27]) and WHtR (mean difference = 0.24 SD [0.21,0.28]) had the strongest associations with the composite unhealthy cardiovascular profile score in women but not in men. CONCLUSIONS:

WC and WHtR were the most useful indices for identifying South Asian adults with prevalent diabetes and hypertension. Collection of waist circumference data in South Asian health surveys will be informative for population-based CVD surveillance efforts.

Creative Commons License
Creative Commons Attribution 4.0
Citation Information
Shivani A. Patel, Mohan Deepa, Roopa Shivashankar, Mohammed K. Ali, et al.. "Comparison of multiple obesity indices for cardiovascular disease risk classification in South Asian adults: The CARRS Study." PLoS One Vol. 12 Iss. 4 (2017) p. 1 - 13
Available at: http://works.bepress.com/zafar_fatmi/69/