Skip to main content
Controlling Amphiphilic Functional Block Copolymers’ Self-Assembly: From Structure to Size
Global Journal of Nanomedicine (2016)
  • Fei Liu
  • Yuan Sun
  • Chen Kang
Nanostructure of self-assembled particles, such as micelles and polymersomes play an important role in drug delivery, especially in tumor therapy. Particles with various structures and proper sizes (20~500 nm) are regarded as perfect candidates for controlled drug delivery due to controllable size that benefits the extended permeation and retention (EPR) and high payload that increases drug delivery efficiency. In this review, we summarized recent representative studies in controlling the size and structure of Amphiphilic block copolymers self-assembled particles with pH- and temperature responsiveness.
  • Nanoparticles; Self-assembly; Size; Structure
Publication Date
Summer June 17, 2016
Citation Information
1. Gu Y, Liu F, Fang C, Qian Z, Achilefu S (2010) In vivo investigation of pharmacokinetics of model drug: comparison of near infrared technique with high-performance liquid chromatography. In Bios (pp. 75760A-75760A).International Society for Optics and Photonics. 2. Kain V, Liu F, Kozlovskaya V, Ingle KA, Khedkar S, et al. (2016) Resolution Agonist 15-epi-Lipoxin A4 Directs FPR2 to Expedite Healing Phase Post-Myocardial Infarction. The FASEB J 30(1): 302-306. 3. Chen J, Chen H, Cui S, Xue B, Tian J, et al. (2012) Glucosamine derivative modified nanostructured lipid carriers for targeted tumor delivery. J Materials Chemistry 22(12): 5770-5783. 4. Xue B, Deng DW, Cao J, Liu F, Li X, et al. (2012) Synthesis of NAC capped near infrared-emitting CdTeS alloyed quantum dots and application for in vivo early tumor imaging. Dalton Transactions 41(16): 4935-4947. 5. Kim SH, Kaplan JA, Sun Y, Shieh A, Sun HL, et al. (2015) The Self‐Assembly of Anticancer Camptothecin–Dipeptide Nanotubes: A Minimalistic and High Drug Loading Approach to Increased Efficacy. Chemistry–A European J 21(1): 101-105. 6. Liu F, Kozlovskaya V, Zavgorodnya O, Martinez-Lopez C, Catledge S, et al. (2014) Encapsulation of anticancer drug by hydrogen-bonded multilayers of tannic acid. Soft matter 10(46): 9237-9247. 7. Deng D, Zhang W, Chen X, Liu F, Zhang J, et al. (2009) Facile Synthesis of High‐Quality, Water‐Soluble, Near‐Infrared‐Emitting PbS Quantum Dots. European J Inorganic Chem 2009(23): 3440-3446. 8. He Y, Li Z, Simone P, Lodge TP (2006) Self-assembly of block copolymer micelles in an ionic liquid. J Am Chem Soc 128(8): 2745-2750. 9. Mai Y, Eisenberg A (2012) Self-assembly of block copolymers. Chemical Society Reviews 41(18): 5969-5985. 10. Cox J K, Eisenberg A, Lennox RB (1999) Patterned surfaces via selfassembly. Current opinion in colloid & interface science 4(1): 52-59. 11. Srinivas G, Discher DE, Klein ML (2004) Self-assembly and properties of diblock copolymers by coarse-grain molecular dynamics. Nature materials 3(9): 638-644. 12. He WD, Sun XL, Wan WM, Pan CY (2011) Multiple morphologies of PAA-b-PSt assemblies throughout RAFT dispersion polymerization of styrene with PAA Macro-CTA. Macromolecules 44(9): 3358-3365. 13. Yusa S, Fukuda K, Yamamoto T, Ishihara K, Morishima Y (2005) Synthesis of well-defined Amphiphilic block copolymers having phospholipids polymer sequences as a novel biocompatible polymer micelle reagent. Biomacromolecules 6(2): 663-670. 14. Dai S, Ravi P, Tam KC (2008) pH-Responsive polymers: synthesis, properties and applications. Soft Matter 4(3): 435-449. 15. Rieger J, Osterwinter G, Bui C, Stoffelbach F, Charleux B (2009) Surfactant-free controlled/living radical emulsion (co) polymerization of n-butyl acrylate and methyl methacrylate via RAFT using Amphiphilic poly (ethylene oxide)-based trithiocarbonate chain transfer agents. Macromolecules 42(15): 5518-5525. 16. Verbrugghe S, Laukkanen A, Aseyev V, Tenhu H, Winnik FM (2003) Light scattering and microcalorimetry studies on aqueous solutions of thermo-responsive PVCL-g-PEO copolymers. Polymer 44(22): 6807- 6814. 17. Beija M, Marty JD, Destarac M (2011) Thermo responsive poly (N-vinyl caprolactam)-coated gold nanoparticles: sharp reversible response and easy tunability. Chemical Communications 47(10): 2826-2828. 18. Liang X, Liu F, Kozlovskaya V, Palchak Z, Kharlampieva E (2015) Thermo responsive micelles from double LCST-poly (3-methyl-Nvinylcaprolactam) block copolymers for cancer therapy. ACS Macro Letters 4(3): 308-311. 19. Liu F, Kozlovskaya V, Medipelli S, Xue B, Ahmad F, et al. (2015) Temperature-sensitive polymersomes for controlled delivery of anticancer drugs. Chemistry of Materials 27(23): 7945-7956. 20. Sun Y, Kang C, Zhang A, Liu F, Hu J, et al. (2016) Co-delivery of dualdrugs with nanoparticles to overcome multidrug resistance. European Journal of Biomedical Research 2(2): 12-18.