© Copyright © 2020 Howari, Ghrefat, Nazzal, Galmed, Abdelghany, Fowler, Sharma, AlAydaroos and Xavier. Copper deposits in the ultramafic rocks of the Semail ophiolite massifs is found to be enormous in the region of northern Oman Mountains, United Arab Emirates. For this study, samples of copper were gathered from 14 different sites in the investigation area and were analyzed in the laboratory using the X-ray diffraction, GER 3700 spectroradiometer, and Inductively Coupled Plasma-Mass Spectrometer. Detection and mapping of copper-bearing mineralized zones were carried out using different image processing approaches of minimum noise fraction, principal component analysis, decorrelation stretch, and band ratio which were applied on Landsat 8 (OLI) data. The spectra of malachite and azurite samples were characterized by broad absorption features in the visible and near infrared region (0.6–1.0 µm). The results obtained from the principal component analysis, minimum noise fraction, band ratio, decorrelation stretch, spectral reflectance analyses, and mineralogical and chemical analyses were found to be similar. Thus, it can be concluded that multispectral Landsat 8 data are useful in the detection iron ore deposits in arid and semi-arid regions.