Article
Collision-Induced Dissociation of Mobility-Separated Ions Using an Orifice-Skimmer Cone at the Back of a Drift Tube
Analytical Chemistry
(2001)
Abstract
An ion mobility-mass spectrometry technique that incorporates
a differentially pumped orifice-skimmer cone
(OSC) region at the exit of the drift tube has been
developed. The OSC region is similar in design to those
used in electrospray ionization sources and offers improvements
in ion transmission (by factors of 5-10
compared with previous designs) and the ability to induce
fragmentation of mobility-separated ions. The separation
of ions prior to dissociation at the skimmer cone allows
the origin of fragment ions to be examined. Here, we
describe the experimental design and demonstrate the
approach by examining fragment ions that are common
to multiple charge states and different gas-phase ion
conformations of electrosprayed angiotensin II and
[Sar1, Val5, Ala8] angiotensin II peptides.
Disciplines
Publication Date
August, 2001
DOI
10.1021/ac010295e
Publisher Statement
Reprinted (adapted) with permission from Analytical Chemistry 73 (2001): 3549, doi: 10.1021/ac010295e. Copyright 2001 American Chemical Society.
Citation Information
Young Jin Lee, Cherokee S. Hoaglund-Hyzer, John A. Taraszka, Gina A. Zientara, et al.. "Collision-Induced Dissociation of Mobility-Separated Ions Using an Orifice-Skimmer Cone at the Back of a Drift Tube" Analytical Chemistry Vol. 73 Iss. 15 (2001) p. 3549 - 3555 Available at: http://works.bepress.com/youngjin-lee/9/