Place meaning has drawn increasing research attention as the cornerstone for better understanding human-place relationship. However, little is understood about what makes the destination meaningful to tourists. Using mixed-method approach, this study fills the gap by investigating the dynamic nature of place meanings in tourist perspective, and exploring the relationships between trip characteristics and destination meanings. The qualitative data analysis revealed 13 themes of destination meanings, while the follow-up quantitative data analysis probed significant influences of trip characteristics on destination meanings. Implications to destination management organizations and tourism practitioners were discussed.