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Biocompatible Flavone-Based Fluorogenic Probes for Quick Wash-Free Mitochondria! Imaging in Living Cells
ACS Applied Materials & Interfaces
  • Bin Liu, University of Akron Main Campus
  • Mickey Shah, University of Akron Main Campus
  • Ge Zhang, University of Akron Main Campus
  • Qin Liu, University of Akron Main Campus
  • Yi Pang, University of Akron Main Campus
Document Type
Article
Publication Date
12-20-2014
Abstract
Mitochondria, vital organelles existing in almost all eukaryotic cells, play a crucial role in energy metabolism and apoptosis of aerobic organisms. In this work, we report two new flavone-based fluorescent probes, MC-Mito1 and MC-Mito2, for monitoring mitochondria in living cells. These two probes exhibit remarkably low toxicity, good cell permeability, and high specificity; these probes complement the existing library of mitochondrial imaging agents. The new dyes give nearly no background fluorescence, and their application does not require tedious postwashing after cell staining. The appreciable tolerance of MC-Mito2 encourages a broader range of biological applications for understanding the cell degeneration and apoptosis mechanism.
Citation Information
Bin Liu, Mickey Shah, Ge Zhang, Qin Liu, et al.. "Biocompatible Flavone-Based Fluorogenic Probes for Quick Wash-Free Mitochondria! Imaging in Living Cells" ACS Applied Materials & Interfaces Vol. 6 Iss. 23 (2014) p. 21638 - 21644
Available at: http://works.bepress.com/yi_pang/5/