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Selected Works of Yeonhwa Park
Article
NF-κB Independent Inhibition of Lipopolysaccharide-Induced Cyclooxygenase by a conjugated Linoleic Acid Cognate
Biochimica et Biophysica Acta (2006)
  • Yeonhwa Park, University of Massachusetts - Amherst
  • G. Li
  • B. Dong
  • D. E Butz
  • M. W Pariza
  • M. E Cook
Abstract
10t, 12c-CLA was shown to inhibit COX-2 expression through the NF-kappaB pathway. In the current study, conjugated nonadecadienoic acid (CNA) was shown to decrease inducible COX-2 protein and mRNA and PGE(2) release to the similar extent as 10t, 12c-CLA in Raw264.7 macrophage. However, unlike 10t, 12c-CLA, inhibition of COX-2 mRNA/protein by CNA was independent of the NF-kappaB pathway. The data indicate the regulation of COX-2 by select conjugated fatty acids and hence their anti-inflammatory actions could operate through different signal transduction pathways.
Disciplines
Publication Date
2006
Citation Information
Yeonhwa Park, G. Li, B. Dong, D. E Butz, et al.. "NF-κB Independent Inhibition of Lipopolysaccharide-Induced Cyclooxygenase by a conjugated Linoleic Acid Cognate" Biochimica et Biophysica Acta (2006)
Available at: http://works.bepress.com/yeonhwa_park/22/