Enhancing Binding Affinity by the Cooperativity between Host Conformation and Host–Guest InteractionsJournal of the American Chemical Society
Publication VersionPublished Version
AbstractGlutamate-functionalized oligocholate foldamers bound Zn(OAc)2, guanidine, and even amine compounds with surprisingly high affinities. The conformational change of the hosts during binding was crucial to the enhanced binding affinity. The strongest cooperativity between the conformation and guest-binding occurred when the hosts were unfolded but near the folding–unfolding transition. These results suggest that high binding affinity in molecular recognition may be more easily obtained from large hosts capable of strong cooperative conformational changes instead of those with rigid, preorganized structures.
Copyright OwnerAmerican Chemical Society
Citation InformationZhenqi Zhong, Xueshu Li and Yan Zhao. "Enhancing Binding Affinity by the Cooperativity between Host Conformation and Host–Guest Interactions" Journal of the American Chemical Society Vol. 133 Iss. 23 (2011) p. 8862 - 8865
Available at: http://works.bepress.com/yan_zhao/9/