Article
Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups
Organic and Biomolecular Chemistry
Document Type
Article
Disciplines
Publication Version
Accepted Manuscript
Publication Date
1-1-2018
DOI
10.1039/C8OB01584H
Abstract
A difficult challenge in synthetic enzymes is the creation of substrate-selective active sites with accurately positioned catalytic groups. Covalent molecular imprinting in cross-linked micelles afforded such active sites in protein-sized, water-soluble nanoparticle catalysts. Our method allowed a systematic tuning of the distance of the catalytic group to the bound substrate. The catalysts displayed enzyme-like kinetics and easily distinguished substrates with subtle structural differences.
Copyright Owner
The Royal Society of Chemistry
Copyright Date
2018
Language
en
File Format
application/pdf
Citation Information
Lan Hu and Yan Zhao. "Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups" Organic and Biomolecular Chemistry Vol. 16 Iss. 31 (2018) p. 5580 - 5584 Available at: http://works.bepress.com/yan_zhao/71/
This is a manuscript of an article published as Hu, Lan, and Yan Zhao. "Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups." Organic & Biomolecular Chemistry 16, no. 31 (2018): 5580-5584. DOI: 10.1039/C8OB01584H. Posted with permission.