Article
Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding
Journal of the American Chemical Society
Document Type
Article
Disciplines
Publication Version
Accepted Manuscript
Publication Date
1-1-2017
DOI
10.1021/jacs.6b12949
Abstract
A general method for sequence-specific binding of peptides remains elusive despite decades of research. By creating an array of “hydrophobically coded dimples” on the surface of surface–core doubly cross-linked micelles, we synthesized water-soluble nanoparticle receptors to recognize peptides by the location, number, and nature of their hydrophobic side chains. Minute differences in the side chains could be distinguished, and affinities up to 20 nM were obtained for biologically active oligopeptides in water.
Copyright Owner
American Chemical Society
Copyright Date
2017
Language
en
File Format
application/pdf
Citation Information
Joseph K. Awino, Roshan W. Gunasekara and Yan Zhao. "Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding" Journal of the American Chemical Society Vol. 139 Iss. 6 (2017) p. 2188 - 2191 Available at: http://works.bepress.com/yan_zhao/62/
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see DOI: 10.1021/jacs.6b12949. Posted with permission.