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Article
Cholic Acid-Derived Facial Amphiphiles with Different Ionic Characteristics
Langmuir
  • Zhenqi Zhong, Iowa State University
  • Jie Yan, Iowa State University
  • Yan Zhao, Iowa State University
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
5-1-2005
DOI
10.1021/la050621b
Abstract
A cholate derivative with three epoxide groups was synthesized from cholic acid by allylation followed by epoxidation. Ring opening of the epoxides by various nucleophiles yielded facial amphiphiles with anionic, cationic, or nonionic functional groups. The critical micelle concentrations of these amphiphiles largely depend on the number of charged groups on the molecule. A facial amphiphile with pH-tunable micellization was prepared. Its aggregation behavior changes abruptly at pH = 7.6−6.6 as a result of protonation of its amino groups.
Comments

Reprinted (adapted) with permission from Langmuir (2005): 6235, doi:10.1021/la050621b. Copyright 2005 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
Zhenqi Zhong, Jie Yan and Yan Zhao. "Cholic Acid-Derived Facial Amphiphiles with Different Ionic Characteristics" Langmuir Vol. 21 Iss. 14 (2005) p. 6235 - 6239
Available at: http://works.bepress.com/yan_zhao/32/