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Article
Tunable Fusion and Aggregation of Liposomes Triggered by Multifunctional Surface-Cross-Linked Micelles
Bioconjugate Chemistry
  • Xueshu Li, Iowa State University
  • Yan Zhao, Iowa State University
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
8-1-2012
DOI
10.1021/bc300082b
Abstract
Water-soluble organic nanoparticles were prepared by cross-linking the micelles of a tripropargylated cationic surfactant by a diazide cross-linker in the presence of Cu(I) catalysts. The nanoparticles were decorated with hydrophilic ligands of different lengths on the surface. By interacting with negatively charged liposomes through tunable electrostatic interactions, these nanoparticles induced fusion and leakage of large unilamellar vesicles (LUVs). Fusion or aggregation of the membranes was highly sensitive to the rigidity and phase structures of the membranes, enabling thermally gated fusion to occur within a very narrow window of temperature change.
Comments

Reprinted (adapted) with permission from Bioconjugate Chemistry 23 (2012): 1721, doi:10.1021/bc300082b. Copyright 2012 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
Xueshu Li and Yan Zhao. "Tunable Fusion and Aggregation of Liposomes Triggered by Multifunctional Surface-Cross-Linked Micelles" Bioconjugate Chemistry Vol. 23 Iss. 9 (2012) p. 1721 - 1725
Available at: http://works.bepress.com/yan_zhao/30/