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Article
Protection/Deprotection of Surface Activity and Its Applications in the Controlled Release of Liposomal Contents
Langmuir
  • Xueshu Li, Iowa State University
  • Yan Zhao, Iowa State University
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
2-1-2012
DOI
10.1021/la2050702
Abstract
The micelles of two tripropargylammonium-functionalized cationic surfactants were cross-linked by a disulfide-containing diazido cross-linker in the presence of Cu(I) catalysts. With multiple residual alkyne groups on the surface, the resulting surface cross-linked micelles (SCMs) were postfunctionalized by reaction with 2-azidoethanol and an azido-terminated poly(ethylene glycol), respectively, via the alkyne–azide click reaction. The water-soluble nanoparticles obtained had low surface activity due to the buried hydrophobic tails. Cleavage of the disulfide cross-links by dithiothreitol (DTT) exposed the hydrophobic tails and resumed surface activity of the “caged” surfactants within 2 min after DTT addition. The controlled breakage of the SCMs was used to lower the surface tension of aqueous solutions and trigger the release of liposomal contents on demand.
Comments

Reprinted (adapted) with permission from Langmuir 28 (2012): 4152, doi:10.1021/la2050702. Copyright 2012 American Chemical Society.

Copyright Owner
American Chemical Society
Language
e
File Format
application/pdf
Citation Information
Xueshu Li and Yan Zhao. "Protection/Deprotection of Surface Activity and Its Applications in the Controlled Release of Liposomal Contents" Langmuir Vol. 28 Iss. 9 (2012) p. 4152 - 4159
Available at: http://works.bepress.com/yan_zhao/26/