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Article
Rationally Designed Cooperatively Enhanced Receptors To Magnify Host–Guest Binding in Water
Journal of the American Chemical Society
  • Roshan W. Gunasekara, Iowa State University
  • Yan Zhao, Iowa State University
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
1-1-2015
DOI
10.1021/ja510823h
Abstract
When disengaged interactions within a receptor are turned on by its guest, these intrahost interactions will contribute to the overall binding energy. Although such receptors are common in biology, their synthetic mimics are rare and difficult to design. By engineering conflictory requirements between intrareceptor electrostatic and hydrophobic interactions, we enabled complementary guests to eliminate the “electrostatic frustration” within the host and turn on the intrahost interactions. The result was a binding constant of Ka >105 M–1 from ammonium–carboxylate salt bridges that typically function poorly in water. These cooperatively enhanced receptors displayed excellent selectivity in binding, despite a large degree of conformational flexibility in the structure.
Comments

Reprinted (adapted) with permission from Journal of the American Chemical Society 137 (2015): 843, doi:10.1021/ja510823h. Copyright 2015 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
Roshan W. Gunasekara and Yan Zhao. "Rationally Designed Cooperatively Enhanced Receptors To Magnify Host–Guest Binding in Water" Journal of the American Chemical Society Vol. 137 Iss. 2 (2015) p. 843 - 849
Available at: http://works.bepress.com/yan_zhao/22/