Catalyzing Methanolysis of Alkyl Halides in the Interior of an Amphiphilic Molecular BasketOrganic Letters
Publication VersionPublished Version
AbstractA molecular basket with four cholate units assembled on a cone-shaped calixarene assumed reversed micelle-like conformation in 5% methanol/carbon tetrachloride. The inwardly facing hydroxyl groups on the cholates concentrated the polar solvent from the mostly nonpolar mixture. Methanolysis of alkyl halides benefited from the concentrated pocket of methanol if the substrate was capable of entering the basket. Substrates that were too large or too hydrophobic to fit within the basket showed no rate acceleration.
Copyright OwnerAmerican Chemical Society
Citation InformationEui-Hyun Ryu, Hongkwan Cho and Yan Zhao. "Catalyzing Methanolysis of Alkyl Halides in the Interior of an Amphiphilic Molecular Basket" Organic Letters Vol. 9 Iss. 25 (2007) p. 5147 - 5150
Available at: http://works.bepress.com/yan_zhao/1/