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Child and adolescent schizophrenia: pharmacological approaches
Psychiatry Publications and Presentations
  • Vishal Madaan, Creighton University
  • Yael Dvir, University of Massachusetts Medical School
  • Daniel R. Wilson, Creighton University
UMMS Affiliation
Department of Psychiatry
Publication Date
Document Type
Adolescent; Age of Onset; Antipsychotic Agents; Child; Diagnosis, Differential; Humans; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology
BACKGROUND: Childhood-onset schizophrenia is a serious, chronic and disabling illness that can significantly affect the quality of life of the affected individuals and their families. The affected children commonly show significant premorbid developmental impairment and social abnormalities that may provide an early clinical clue to pursue treatment. Until recent times, treatment approaches for childhood schizophrenia were derived from the adult population. However, given the unique developmental challenges in the pediatric population, this extrapolation may not hold true. OBJECTIVE: This review encompasses and elaborates on the efficacy, safety and tolerability data available at present for both typical and atypical antipsychotics for treatment of childhood schizophrenia. METHOD: A literature search was conducted on PUBMED with special emphasis on double-blind placebo-controlled studies in childhood schizophrenia. Data from similar studies presented in recent meetings were also added to the review. CONCLUSIONS: Recent research in pediatric psychopharmacology has led to the Food and Drug Administration's approval of two atypical antipsychotics for the treatment of schizophrenia. Although data in this age group are still sparse, research in this unique population has grown over the years.
DOI of Published Version
Expert Opin Pharmacother. 2008 Aug;9(12):2053-68. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Vishal Madaan, Yael Dvir and Daniel R. Wilson. "Child and adolescent schizophrenia: pharmacological approaches" Vol. 9 Iss. 12 (2008) ISSN: 1465-6566 (Linking)
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