Article
Oriented Immobilized Sialyloligo-macroligand Microarray
Macro-Glycoligands: Methods and Protocols
Document Type
Contribution to Books
Publication Date
11-8-2015
Disciplines
Abstract
Silaic acid is the most common terminal glycan on cell surface glycoproteins and glycolipids, involving in many biological processes. Studying interactions between multivalent sialic acid scaffolds and proteins binding to it will give incredible information in understanding the biological process the sialic acid is involved in. Here we describe chemoenzymatic synthesis of chain-end functionalized sialyllactose-containing glycopolymers with different linkages and their oriented immobilization for glycoarray and SPR-based glyco-biosensor applications.
DOI
10.1007/978-1-4939-3130-9_16
Citation Information
Narla, S. N.; Sun, X. Oriented Immobilized Sialyloligo-macroligand Microarray. In Macro-Glycoligands: Methods and Protocols; Sun, X., Ed.; Springer New York: New York, NY, 2016; pp 195-206.
This work was supported from AHA Grant-in Aid grant, Ohio Research Scholars Program grant, NSF MRI grant, and Doctoral Dissertation Research Expense Award Program (Cleveland State University).