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Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats
Biopharmaceutics & drug disposition
  • Xinyu Wang, Philadelphia College of Osteopathic Medicine
  • Jihai Pang
  • Jacqueline A. Maffucci
  • Devandra S. Patel
  • Robert A. Newman
  • Sean M. Kerwin
  • Phillip D. Bowman
  • Salomon Stavchansky
Document Type
Article
Publication Date
1-1-2009
Abstract
The pharmacokinetic profiles of caffeic acid phenethyl ester (CAPE) and its catechol-ring fluorinated derivative (FCAPE) were determined in rats after intravenous administration of 5, 10 or 20 mg/kg for CAPE and 20 mg/kg for FCAPE, respectively. The plasma concentrations of CAPE and FCAPE were measured using a validated liquid chromatography tandem mass spectrometric method. The pharmacokinetic parameters were estimated using non compartmental analysis (NCA) and biexponential fit. The results showed that the area under the plasma concentration-time curve for CAPE treatment increased in a proportion greater than the increase in dose from 5 to 20 mg/kg of CAPE. Total body clearance values for CAPE ranged from 42.1 to 172 ml/min/kg (NCA) and decreased with the increasing dose of CAPE. Similarly, the volume of distribution values for CAPE ranged from 1555 to 5209 ml/kg, decreasing with increasing dose. The elimination half-life for CAPE ranged from 21.2 to 26.7 min and was independent of dose. That FCAPE was distributed extensively into rat tissues and eliminated rapidly was indicated by a high value of volume of distribution and similar short elimination half-life as that of CAPE.
Comments

This article was published in Biopharmaceutics & drug disposition, Volume 30, Issue 5, Pages 221-228.

The published version is available at http://dx.doi.org/10.1002/bdd.657 [doi].

Copyright © 2009 Wiley.

Citation Information
Xinyu Wang, Jihai Pang, Jacqueline A. Maffucci, Devandra S. Patel, et al.. "Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats" Biopharmaceutics & drug disposition Vol. 30 Iss. 5 (2009) p. 221 - 228
Available at: http://works.bepress.com/xinyu_wang/8/