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Article
Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells
Bioorganic & medicinal chemistry
  • Xinyu Wang, Philadelphia College of Osteopathic Medicine
  • Salomon Stavchansky
  • Phillip D. Bowman
  • Sean M. Kerwin
Document Type
Article
Publication Date
1-1-2006
Abstract
Caffeic acid phenethyl ester (CAPE), a natural polyphenolic compound with many biological activities, has been shown to be protective against ischemia-reperfusion injury. We have synthesized six new catechol ring-fluorinated CAPE derivatives and evaluated their cytotoxic and cytoprotective effects against menadione-induced cytotoxicity in human umbilical vein endothelial cells. These results provide some insights into the structural basis of CAPE cytoprotection in this assay, which does not appear to be based solely on direct antioxidant properties.
Comments

This article was published in Bioorganic & medicinal chemistry, Volume 14, Issue 14, Pages 4879-4887.

The published version is available at http://dx.doi.org/10.1016/j.bmc.2006.03.015.

Copyright © 2006 .

Citation Information
Xinyu Wang, Salomon Stavchansky, Phillip D. Bowman and Sean M. Kerwin. "Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells" Bioorganic & medicinal chemistry Vol. 14 Iss. 14 (2006) p. 4879 - 4887
Available at: http://works.bepress.com/xinyu_wang/5/