pH-Triggered conformational switches based on trans-2-aminocyclohexanol moiety241st National Meeting and Exposition of the American Chemical Society (ACS)
OrganizationAmerican Chemical Society (ACS)
Conference DatesMarch 27-31, 2011
Date of Presentation3-29-2011
AbstractProperly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can serve as powerful conformational pH-triggers. Their protonation leads to a conformational flip due to a strong intramolecular hydrogen bond. This 'impulse' is mechanically transmitted by the cycle to induce a conformational change of a remote site, thus altering its properties. Variation of NR2 groups allows a tuning of the conformational equilibrium, which was studied by NMR. These triggers were used in pH-sensitive lipid vesicles for drug and gene delivery.
Citation InformationVyacheslav V. Samoshin, Yu Zheng, Xin Liu, Nataliya M. Samoshina, et al.. "pH-Triggered conformational switches based on trans-2-aminocyclohexanol moiety" 241st National Meeting and Exposition of the American Chemical Society (ACS) (2011) ISSN: 2572-6803
Available at: http://works.bepress.com/xin-guo/60/