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Presentation
Synthesis and characterization of a hydrazone based pH-sensitive lipid polymer conjugate
242nd National Meeting and Exposition of American Chemical Society (ACS)
  • Vijay Gyanani, University of the Pacific
  • Xin Guo, University of the Pacific
Document Type
Poster
Organization
American Chemical Society (ACS)
Location
Denver, CO
Conference Dates
August 28-September 1, 2011
Date of Presentation
8-28-2011
Abstract

A three-step synthesis of a lipid-polymer conjugate is presented. The lipid, 1,2-di-O-hexadecyl-rac-glycerol (DHG) is conjugated to polyethylene glycol 2000 (PEG2000) via a pH-sensitive hydrazone linker. The steps involved in the synthesis of the conjugate include 1) incorporation of an ester group on the DHG moiety 2) hydrozinolysis of the ester group to yield a DHG hydrazide 3) condensation of the DHG hydrazide with m-PEG2000 aldehyde to yield the DHG-Hydrazone-PEG2000 conjugate. This hydrazone-based conjugate shows a pH-dependent hydrolysis and can be incorporated into liposomes to trigger cargo release at low pH environments as in cancer tissues.

Citation Information
Vijay Gyanani and Xin Guo. "Synthesis and characterization of a hydrazone based pH-sensitive lipid polymer conjugate" 242nd National Meeting and Exposition of American Chemical Society (ACS) (2011)
Available at: http://works.bepress.com/xin-guo/51/