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Presentation
Fliposomes: Stimuli-triggered conformational flip of novel amphiphiles causes an instant cargo release from liposomes
248th American Chemical Society (ACS) National Meeting
  • Vyacheslav V. Samoshin, University of the Pacific
  • Nataliya M. Samoshina, University of the Pacific
  • Xin Liu, University of the Pacific
  • Yu Zheng, University of the Pacific
  • Andreas H. Franz, University of the Pacific
  • Xin Guo, University of the Pacific
Document Type
Conference Presentation
Department
Chemistry
Organization
American Chemical Society (ACS)
Location
San Francisco, CA
Conference Dates
August 10-14, 2014
Date of Presentation
8-11-2014
Disciplines
Abstract
New developments are presented in the design of stimuli-responsive liposomes for targeted delivery via the construction of a liposome membrane (lipid bilayer) using amphiphiles able to perform a stimuli-triggered conformational flip (“flipids”). When done simultaneously by a major or significant part of the bilayer molecules, this massive flip disrupts the liposome membrane and induces a rapid release of the liposome load specifically in response to the initial stimulus. The conformational switches incorporated into the amphiphilic molecules could potentially be controlled by various internal or external factors (pH, metal complexation, light, etc.). Using this concept we designed a series of pH-triggerable “flipids”, and prepared and tested “fliposomes” with extraordinary characteristics: high stability in storage and in serum combined with an instant release of their cargo in response to a weakly acidic medium.
Citation Information
Vyacheslav V. Samoshin, Nataliya M. Samoshina, Xin Liu, Yu Zheng, et al.. "Fliposomes: Stimuli-triggered conformational flip of novel amphiphiles causes an instant cargo release from liposomes" 248th American Chemical Society (ACS) National Meeting (2014)
Available at: http://works.bepress.com/xin-guo/5/