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Article
Chemical approaches to triggerable lipid vesicles for drug and gene delivery
Accounts of Chemical Research
  • Xin Guo, University of California, San Francisco
  • Francis C. Szoka, Jr., University of California, San Francisco
Document Type
Article
DOI
10.1021/ar9703241
Publication Date
3-8-2003
Abstract
Effective drug delivery requires the precise spatial and temporal delivery of therapeutic agents to the target site. To this end, a variety of chemical and physicochemical approaches have been devised to create lipid vesicles (liposomes) that can be triggered to release their contents in a controlled fashion. The triggers include changes in pH, redox potential, temperature, or the level of specific enzymes. We review the chemistries that have recently been applied to exploit the pH and redox potential triggers so as to release vesicle contents in the appropriate biological location.
Citation Information
Xin Guo and Francis C. Szoka. "Chemical approaches to triggerable lipid vesicles for drug and gene delivery" Accounts of Chemical Research Vol. 36 Iss. 5 (2003) p. 335 - 341 ISSN: 0001-4842
Available at: http://works.bepress.com/xin-guo/26/