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Selected Works of Xin Guo
Presentation
Optimization of doxorubicin-loaded anticancer liposomes with a pH-sensitive conformational switch
Pacific Research & Scholarship Day
  • Yifan Lu, University of the Pacific
  • Shen Zhao, University of the Pacific
  • Xin Guo, University of the Pacific
Lead Author Affiliation
Pharmaceutics and Drug Design
Introduction/Abstract

Doxorubicin is an anthracyline drug widely used in clinical as a broad spectrum anti-cancer drug to treat several cancers. It intercalates between base pairs in the DNA helix and inhibit topoisomerase II, preventing DNA replication. However, cardiotoxicity and renal damage has limited its application. Thus, selective accumulation of doxorubicin at the tumor site becomes a critical step of better therapeutic outcome.

Location
DUC Ballroom A&B
Format
Poster Presentation
Citation Information
Yifan Lu, Shen Zhao and Xin Guo. "Optimization of doxorubicin-loaded anticancer liposomes with a pH-sensitive conformational switch" (2016)
Available at: http://works.bepress.com/xin-guo/17/