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Presentation
NMR investigation of phospholipid/PEG-ceramide-liposomes
241st American Chemical Society (ACS) National Meeting & Exposition
  • Andreas H. Franz, University of the Pacific
  • Nataliya M. Samoshina, University of the Pacific
  • Xin Guo, University of the Pacific
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Conference Presentation
Department
Chemistry
Organization
American Chemical Society (ACS)
Location
Anaheim, CA
Conference Dates
March 27-31, 2011
Date of Presentation
3-28-2011
Disciplines
Abstract
Liposomes are macromolecular structures in which an aqueous core is surrounded by a double-layered lipid membrane. Surface modifications in liposomes serve the purpose of enhanced water-solubility, immuno-compatibility, and targeted delivery of liposome “cargo”, e.g. drugs or DNA/RNA. Liposomal drug delivery systems are frequently composed of phospho-lipids and ceramides amongst others. We investigated pH-sensitive liposomes. Complete NMR structure assignment and quantification of all components provided quality control. During liposome extrusion/preparation/loading and cleanup, little to no variation in composition was observed.
Citation Information
Andreas H. Franz, Nataliya M. Samoshina, Xin Guo and Vyacheslav V. Samoshin. "NMR investigation of phospholipid/PEG-ceramide-liposomes" 241st American Chemical Society (ACS) National Meeting & Exposition (2011)
Available at: http://works.bepress.com/xin-guo/16/