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Presentation
Trans-2-Aminocyclohexanol-based lipids as pH-sensitive conformational switches for the PEG-grafted liposomes
239th American Chemical Society (ACS) National Meeting
  • Nataliya M. Samoshina, University of the Pacific
  • Xin Guo, University of the Pacific
  • Barbora Brazdova, University of the Pacific
  • Yu Zheng, University of the Pacific
  • Xin Liu, University of the Pacific
  • Andreas H. Franz, University of the Pacific
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Poster
Department
Chemistry
Organization
American Chemical Society (ACS)
Location
San Francisco, CA
Conference Dates
March 21-25, 2010
Date of Presentation
3-24-2010
Disciplines
Abstract
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: a protonation-induced conformational change of the built-in trans-2-aminocyclohexanol moiety. In liposomes, this ring flip loosens packing of the attached lipid tails, leading to contents leakage. Herein we report our latest studies on the pH-sensitivity of various PEG-grafted (sterically hindered) liposomes comprising trans-2-aminocyclohexanol-based lipids. These liposomes are stable at pH 7.4 and yet release their content in a few seconds at pH 5.3-5.5.
Citation Information
Nataliya M. Samoshina, Xin Guo, Barbora Brazdova, Yu Zheng, et al.. "Trans-2-Aminocyclohexanol-based lipids as pH-sensitive conformational switches for the PEG-grafted liposomes" 239th American Chemical Society (ACS) National Meeting (2010)
Available at: http://works.bepress.com/xin-guo/12/