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Presentation
Novel amphiphiles for pH-sensitive liposomes with trans-2-aminocyclohexanol-based conformational switch and the simplified models thereof
243rd American Chemical Society (ACS) National Meeting & Exposition
  • Yu Zheng, University of the Pacific
  • Xin Liu, University of the Pacific
  • Nataliya M. Samoshina, University of the Pacific
  • Andreas H. Franz, University of the Pacific
  • Xin Guo, University of the Pacific
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Conference Presentation
Department
Chemistry
Organization
American Chemical Society (ACS)
Location
San Diego, CA
Conference Dates
March 25-March 29, 2012
Date of Presentation
3-26-2012
Disciplines
Abstract
We suggested recently a novel type of pH-sensitive delivery system, "fliposomes", which contain trans-2-aminocyclohexanol-based amphiphiles that perform a conformational flip and trigger an instant cargo release in acidic media. A series of new “flipids” has been synthesized, and a good correlation between their conformational switch and the leakage of flipsomes has been observed. The diethyl esters of similar structure were shown to be good models for prediction of the flipids' conformational behavior.
Citation Information
Yu Zheng, Xin Liu, Nataliya M. Samoshina, Andreas H. Franz, et al.. "Novel amphiphiles for pH-sensitive liposomes with trans-2-aminocyclohexanol-based conformational switch and the simplified models thereof" 243rd American Chemical Society (ACS) National Meeting & Exposition (2012)
Available at: http://works.bepress.com/xin-guo/10/