Article
VoPo leverages cellular heterogeneity for predictive modeling of single-cell data
Nature Communications
Department
Biomedical Sciences
Document Type
Article
DOI
10.1038/s41467-020-17569-8
Publication Date
12-1-2020
Disciplines
Abstract
High-throughput single-cell analysis technologies produce an abundance of data that is critical for profiling the heterogeneity of cellular systems. We introduce VoPo (https://github.com/stanleyn/VoPo), a machine learning algorithm for predictive modeling and comprehensive visualization of the heterogeneity captured in large single-cell datasets. In three mass cytometry datasets, with the largest measuring hundreds of millions of cells over hundreds of samples, VoPo defines phenotypically and functionally homogeneous cell populations. VoPo further outperforms state-of-the-art machine learning algorithms in classification tasks, and identified immune-correlates of clinically-relevant parameters.
Creative Commons License
Creative Commons Attribution 4.0 International
Citation Information
Natalie Stanley, Ina A. Stelzer, Amy S. Tsai, Ramin Fallahzadeh, et al.. "VoPo leverages cellular heterogeneity for predictive modeling of single-cell data" Nature Communications Vol. 11 Iss. 1 (2020) ISSN: 2041-1723 Available at: http://works.bepress.com/xiaoyuan-han/51/