Article
Mechanism of resilin elasticity
Nature Communications
(2012)
Abstract
Resilin is critical in the flight and jumping systems of insects as a polymeric rubber-like protein with outstanding elasticity. However, insight into the underlying molecular mechanisms responsible for resilin elasticity remains undefined. Here we report the structure and function of resilin from Drosophila CG15920. A reversible beta-turn transition was identified in the peptide encoded by exon III and for full-length resilin during energy input and release, features that correlate to the rapid deformation of resilin during functions in vivo. Micellar structures and nanoporous patterns formed after beta-turn structures were present via changes in either the thermal or the mechanical inputs. A model is proposed to explain the super elasticity and energy conversion mechanisms of resilin, providing important insight into structure–function relationships for this protein. Furthermore, this model offers a view of elastomeric proteins in general where beta-turn-related structures serve as fundamental units of the structure and elasticity.
Keywords
- Entomology,
- Molecular biophysics,
- Structural biology
Disciplines
Publication Date
August, 2012
DOI
10.1038/ncomms2004
Citation Information
Guokui Qin, Xiao Hu, Peggy Cebe and David L. Kaplan. "Mechanism of resilin elasticity" Nature Communications Vol. 3 (2012) ISSN: 2041-1723 Available at: http://works.bepress.com/xiao-hu/6/