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Article
Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells
Proceedings in Obstetrics and Gynecology
  • Xiangbing Meng, University of Iowa
  • Pavla Brachova, University of Iowa
  • Shujie Yang, University of Iowa
  • Zhi Xiong, University of Iowa
  • Yuping Zhang, University of Iowa
  • Kimberly K. Leslie, University of Iowa
Peer Reviewed
0
Publication Date
7-28-2011
Abstract
Understanding the molecular mechanisms of chemoresistance is vital to design therapies to restore chemosensitivity. MTDH mediates drug resistance by regulating expression of genes required for the control of apoptosis and cell cycle. These findings indicate that sensitivity to chemotherapy agents and combination treatment with HDAC inhibitor and TRAIL can be restored by manipulating MTDH, and hence depletion of MTDH is a potentially novel avenue for effective cancer therapy.
Keywords
  • MTDH,
  • Metadherin,
  • TRAIL,
  • LBH 589,
  • HDAC
Total Pages
2
Rights
Copyright © Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang, and Kimberly K. Leslie, 2011.
Creative Commons License
Creative Commons Attribution 3.0
Citation Information
Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, et al.. "Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells" (2011) p. 1 - 2 ISSN: 2154-4751
Available at: http://works.bepress.com/xiangbing_meng/2/