To the Editor: Alcohol induced hepatic oxidative stress and inflammation is known to cause liver injury. An increase in reactive oxidative species (ROS) from alcohol consumption leads to oxidative stress . This can activate the inflammatory cytokines, IL-6 and TNF-α which promote liver injury. Both IL-6 and TNF-α are activated and transcribed by the inflammatory molecule, NFκB . We read the interesting paper by Liu et al., entitled, “Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulating in rats”, published in your journal recently . The authors demonstrated that oleanolic acid can reduce hepatic injury by elevating Nrf-2 related antioxidants, reduce inflammation, and increase ethanol metabolism. We believe that the mechanism of modulating these signalling pathways could be important for understanding the protective effects of oleanolic acid.
Available at: http://works.bepress.com/xhuang/191/