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Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics
Illawarra Health and Medical Research Institute
  • Mei Han, University of Wollongong
  • Xiang Yang Zhang, Peking University
  • Da Chun Chen, Peking University
  • Yun Long Tan, Peking University
  • Chong Sheng Song, Peking University
  • Yinghua Yu, University of Wollongong
  • Xu-Feng Huang, University of Wollongong
Publication Date
1-1-2015
RIS ID
95934
Publication Details

Han, M., Zhang, X., Chen, D., Tan, Y., Song, C., Yu, Y. & Huang, X. (2015). Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics. International Clinical Psychopharmacology, 30 (2), 89-95.

Abstract
Cognitive deficits are a core feature of schizophrenia. There is ongoing debate on whether cognition is affected by antipsychotic drugs (APDs). This study examined the effect of long-term treatment with APDs on cognition in schizophrenia. Cognitive function was assessed in 418 patients with schizophrenia on long-term treatment with APDs (215 on clozapine, 91 on risperidone and 112 on typical APDs) and 159 healthy controls using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Schizophrenia symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS). We found that cognitive test scores were significantly lower in all patients compared with the healthy controls on almost all of the total and subscores of RBANS (all P<0.001), except for the visuospatial/constructional index. Individuals taking clozapine showed worse immediate and delayed memory performance than those taking typical APDs (all P<0.01). Moreover, individuals taking clozapine showed better language performance than those taking risperidone (P<0.01). Immediate memory and delayed memory were modestly correlated with the types of APDs and the PANSS negative scores. Our results show that individuals taking clozapine performed worse in immediate and delayed memory than those taking typical APDs, but exemplified better language performance than those taking risperidone.
Grant Number
NHMRC/MH635245
Citation Information
Mei Han, Xiang Yang Zhang, Da Chun Chen, Yun Long Tan, et al.. "Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics" (2015) p. 89 - 95
Available at: http://works.bepress.com/xhuang/182/