Skip to main content
Article
Alterations of NMDA receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats
Faculty of Science, Medicine and Health - Papers
  • Qing Wang, University of Wollongong
  • Jin Li, Third Affiliated Hospital of Sun Yat-sen University
  • Xiaobo Wei, Third Affiliated Hospital of Sun Yat-sen University
  • Jinchi Liao, Third Affiliated Hospital of Sun Yat-sen University
  • Yunqi Xu, Third Affiliated Hospital of Sun Yat-sen University
  • Tingting Lu, Third Affiliated Hospital of Sun Yat-sen University
  • Bing Qin, Third Affiliated Hospital of Sun Yat-sen University
  • Junqiang Xie, Third Affiliated Hospital of Sun Yat-sen University
  • Chao Deng, University of Wollongong
  • Xu-Feng Huang, University of Wollongong
RIS ID
90367
Publication Date
1-1-2014
Publication Details

Wang, Q., Li, J., Wei, X., Liao, J., Xu, Y., Lu, T., Qin, B., Xie, J., Deng, C. & Huang, X. (2014). Alterations of NMDA receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats. International Journal of Neuroscience, 124 (6), 457-465.

Abstract
The N-methyl-d-aspartate (NMDA) system closely interacts with the dopaminergic system and is strongly implicated in the pathophysiological mechanisms and therapeutic paradigms of Parkinson's disease. This study aims to systematically investigate the changes of NMDA receptors in a wide range of brain structures 3 weeks after unilateral medial forebrain bundle lesion by 6-hydroxydopamine (6-OHDA). NMDA receptor distributions and alterations in the post-mortem rat brain were detected by [(3)H] MK-801 binding autoradiography. In the 6-OHDA-induced Parkinsonian rat model, nigrostriatal dopaminergic neuron loss significantly mediated the decreased [(3)H] MK-801 binding, predominantly in the hippocampus (-22.4%, p < 0.001), caudate putamen (-14.1%, p < 0.01), accumbens nucleus (-13.8%, p < 0.05), cingulate cortex (-13.4%, p < 0.001), posteromedial cortical amygdala (-14.5%, p < 0.01) and piriform cortex (-9%, p < 0.05) compared to the controls, while there was a profound reduction of tyrosine hydroxylase (TH) immunohistochemistry in the substantia nigra pars compacta. Alterations in [(3)H] MK-801 in the specific brain regions related to cognitive functions may indicate that cognitive dysfunctions caused by 6-OHDA lesion were via the NMDA system. The downregulation of NMDA receptor binding in the present study provides indirect evidence for plasticity in the NMDA system in the rat brain. The present study improves our understanding of the critical roles of the NMDA receptors in treating neurodegenerative disorders, and implicates NMDA receptors as a novel therapeutic target in the treatment of Parkinson's disease.
Grant Number
NHMRC/514640
Citation Information
Qing Wang, Jin Li, Xiaobo Wei, Jinchi Liao, et al.. "Alterations of NMDA receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats" (2014)
Available at: http://works.bepress.com/xhuang/162/