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Altered IL-2, IL-6 and IL-8 serum levels in schizophrenia patients with tardive dyskinesia
Illawarra Health and Medical Research Institute
  • Hui-Mei An, Peking University
  • Yun Long Tan, Peking University
  • Jing Shi, Peking University
  • Zhi-Ren Wang, Peking University
  • Jair C Soars, University of Texas Health Science Center at Houston
  • Jing Qin Wu, University of Newcastle
  • Fu-De Yang, Peking University
  • Xu-Feng Huang, University of Wollongong
  • Xiang Yang Zhang, Peking University
RIS ID
97806
Publication Details

An, H., Tan, Y., Shi, J., Wang, Z., Soars, J. C., Wu, J., Yang, F., Huang, X. & Zhang, X. (2015). Altered IL-2, IL-6 and IL-8 serum levels in schizophrenia patients with tardive dyskinesia. Schizophrenia Research, 162 (1-3), 261-268.

Abstract

Immune deregulation has been postulated to be one of the mechanisms underlying the pathogenesis of tardive dyskinesia (TD). We hypothesized that interleukins would have a link with TD in schizophrenia patients. In this study, the serum IL-2, IL-6 and IL-8 levels were examined by enzyme-linked immunosorbent assay (ELISA) in schizophrenia patients with TD (n = 48) and without TD (n = 45), and healthy controls (n = 44). The psychopathological symptoms of schizophrenia were assessed by the Positive and Negative Syndrome Scale (PANSS). The severity of TD was evaluated using Abnormal Involuntary Movement Scale (AIMS). The results showed that serum IL-2, IL-6 and IL-8 levels were significantly different among schizophrenia patients with TD and without TD and normal controls. Moreover, IL-2 level was significantly correlated with PANSS positive subscale and general subscale in patients with TD and without TD. In addition, IL-2 level was positively correlated with AIMS score in TD patients. The results supported that immune disturbance is related to the schizophrenia patients, especially to the patients with TD and ILs might play an important role in the pathophysiology of schizophrenia patients with TD.

Citation Information
Hui-Mei An, Yun Long Tan, Jing Shi, Zhi-Ren Wang, et al.. "Altered IL-2, IL-6 and IL-8 serum levels in schizophrenia patients with tardive dyskinesia" (2015) p. 261 - 268
Available at: http://works.bepress.com/xhuang/160/