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Article
Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN
Faculty of Science, Medicine and Health - Papers
  • Yan-Chuan Shi, Garvan Institute of Medical Research
  • Jackie Lau, Garvan Institute of Medical Research
  • Zhou Lin, Garvan Institute of Medical Research
  • Hui Zhang, Garvan Institute of Medical Research
  • Lei Zhai, Garvan Institute of Medical Research
  • Guenther Sperk, Medical University Innsbruck
  • Regine Heilbronn, Charite Universitatsmedizin
  • Mario Mietzsch, Charite Universitatsmedizin
  • Stefan Weger, Charite Universitatsmedizin
  • Xu-Feng Huang, University of Wollongong
  • Ronaldo F Enriquez, Garvan Institute of Medical Research
  • Lesley Castillo, Garvan Institute of Medical Research
  • Paul A Baldock, Garvan Institute of Medical Research
  • Lei Zhang, Garvan Institute of Medical Research
  • Amanda Sainsbury, University of Sydney
  • Herbert Herzog, Garvan Institute of Medical Research
  • Shu Lin, Garvan Institute of Medical Research
RIS ID
75352
Publication Date
1-1-2013
Publication Details

Shi, Y., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X., Enriquez, R. F., Castillo, L., Baldock, P. A., Zhang, L., Sainsbury, A., Herzog, H. & Lin, S. 2013, 'Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN', Cell Metabolism, vol. 17, no. 2, pp. 236-248.

Abstract

Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) and other regions in the brainstem. Consistent with this, Arc NPY signaling decreased sympathetically innervated BAT thermogenesis, involving the downregulation of uncoupling protein 1 (UCP1) expression in BAT. Taken together, these data reveal a powerful Arc-NPY-regulated neuronal circuit that controls BAT thermogenesis and sympathetic output via TH neurons.

Citation Information
Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, et al.. "Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN" (2013)
Available at: http://works.bepress.com/xhuang/133/