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The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia
Faculty of Health and Behavioural Sciences - Papers (Archive)
  • Li Hui, Jilin University
  • Xuan Zhang, Jilin University
  • Xu-Feng Huang, University of Wollongong
  • Mei Han, University of Wollongong
  • Francesca Fernandez, University of Wollongong
  • Yaqin Yu, Jilin University
  • ShiLong Sun, Jilin University
  • Wenjun Li, Jilin University
  • Da Chun Chen, Peking University
  • Mei Hong Xiu, Peking University
  • Thomas R Kosten, Baylor College of Medicine
  • Xiang Yang Zhang, Baylor College of Medicine
RIS ID
57431
Publication Date
1-1-2012
Publication Details

Hui, L., Zhang, X., Huang, X. Feng., Han, M., Fernandez, F., Yu, Y., Sun, S., Li, W., Chen, D. Chun., Xiu, M. Hong., Kosten, T. R. & Zhang, X. Yang. (2012). The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia. Journal of Psychiatric Research, 46 (6), 733-737.

Abstract

Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH50-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results:We showedthat theDBH50-Ins/Del deletion (Del) allelic and genotypic frequencieswere significantly lower in controls than first-episode of schizophrenics (FES) (both p < 0.001), but controlswere not different from chronic schizophrenics. Furthermore, the PANSS positive symptom and total scores were significantly higher in FES with the Del/Del genotype than those with Ins/Del and Ins/Ins genotypes (all p < 0.05). Conclusions: The DBH50-Ins/Del polymorphism may play a role in susceptibility to the positive symptoms of FES and to these FES not progressing on to chronic schizophrenia.

Citation Information
Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, et al.. "The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia" (2012) p. 733 - 737
Available at: http://works.bepress.com/xhuang/120/