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Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains
Faculty of Health and Behavioural Sciences - Papers (Archive)
  • Chang-Hua Hu, University of Wollongong
  • Chao Deng, University of Wollongong
  • Nikolce Mackovski, University of Wollongong
  • Ling Long, Sun Yat-Sen University of Medical Sciences
  • Cansheng Zhu, Sun Yat-Sen University of Medical Sciences
  • Yu Yang, Sun Yat-Sen University of Medical Sciences
  • Yuge Wang, Sun Yat-Sen University of Medical Sciences
  • J-Z Chen, University of Wollongong
  • Xu-Feng Huang, University of Wollongong
  • Qing Wang, University of Wollongong
RIS ID
33427
Publication Date
1-1-2010
Publication Details

Hu, C., Wang, Y., Wang, Q., Deng, C., Yang, Y., Chen, J., Huang, X., Long, L., Zhu, C. & Mackovski, N. (2010). Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34 (8), 1419-1425.

Abstract

Statins have been widely used for the treatment of a variety of medical conditions including psychoneurological disorders beyond their original use in lowering cholesterol. Histamine receptors play an important role in the regulation of neural activity, however, it is unknown whether statins act on histamine receptors, particularly for their neural regulatory effects. This study examined the effects of simvastatin and 6-hydroxydopamine (6-OHDA) lesions on histamine H1 receptors using [3H] pyrilamine binding autoradiography. Compared to the saline group, simvastatin (1 mg/kg/day) significantly decreased H1 receptor bindings in the primary motor cortex (M1), ventromedial hypothalamic nucleus (VMH), caudate putamen (CPu), accumbens core (AcbC) and prefrontal cortex (PfC) (all pb0.05); however 10 mg/kg/day simvastatin increased H1 receptor density only in the medial amygdaloid nucleus (Mep) (pb0.05), but had no significant effect in other regions examined. The 6-OHDA lesion did not alter H1 receptor binding density in most brain areas, except a trend decrease in the hippocampus (p=0.07) and a trend increase in the cingulate cortex (p=0.06). These results suggested that simvastatin has different effects on the H1 receptors in different rat brain regions depending on the doses. Therefore, simvastatin can modulate histaminergic neurotransmission in the brain, and support the role of H1 receptors in psychoneurological disorders.

Grant Number
NHMRC/514640
Citation Information
Chang-Hua Hu, Chao Deng, Nikolce Mackovski, Ling Long, et al.. "Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains" (2010)
Available at: http://works.bepress.com/xhuang/104/