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Increases in peptide Y-Y levels following oat β-glucan ingestion are dose-dependent in overweight adults
Faculty of Science, Medicine and Health - Papers
  • Eleanor J Beck, University of Wollongong
  • Linda C Tapsell, University of Wollongong
  • Marijka J Batterham, University of Wollongong
  • Susan M Tosh, Agriculture and Agri-Food Canada
  • Xu-Feng Huang, University of Wollongong
RIS ID
30761
Publication Date
1-1-2009
Publication Details

Beck, E. J., Tapsell, L. C., Batterham, M. J., Tosh, S. M. & Huang, X. (2009). Increases in peptide Y-Y levels following oat β-glucan ingestion are dose-dependent in overweight adults. Nutrition Research, 29 (10), 705-709.

Abstract

Peptide Y-Y (PYY) is an anorexigenic hormone implicated in appetite control, and β-glucan is a fiber known to affect appetite. We hypothesized that plasma PYY levels would increase in overweight human adults consuming increasing doses of β-glucan. The objective was to test whether the effect could be seen with β-glucan delivered through extruded cereals containing a high β-glucan oat bran with demonstrated high molecular weight and solubility. Fourteen subjects consumed a control meal and 3 cereals of varying β-glucan concentration (between 2.2 and 5.5 g), and blood samples were collected over 4 hours. Analysis of raw PYY data showed a trend toward significant increases over 4 hours. An increasing dose of β-glucan resulted in higher levels of plasma PYY, with significant differences between groups from 2 to 4 hours post test-meal. Data for the area under the curve analysis also approached significance, with post hoc analysis showing a difference (P = .039) between the control and the highest dose of β-glucan (5.5 g). The PYY levels at 4 hours were significantly different between the control and high-dose meal test (P = .036). There was a significant dose response, with a positive correlation between the grams of β-glucan and PYY area under the curve (r2 = 0.994, P = .003). The optimal dose of β-glucan appears to lie between 4 and 6 g, with the effects on PYY mediated by viscosity and concentration. Meal-test studies examining a range of hormones should measure hormones over a minimum of 4 hours and record meal intake for even longer time frames.

Citation Information
Eleanor J Beck, Linda C Tapsell, Marijka J Batterham, Susan M Tosh, et al.. "Increases in peptide Y-Y levels following oat β-glucan ingestion are dose-dependent in overweight adults" (2009)
Available at: http://works.bepress.com/xhuang/100/