Continuous Professional Development offers nurses the opportunity to improve their knowledge, skills and also improve their performance in the healthcare setting. The purpose of the study was to examine if there is a relationship between continuous Professional Development and Job Performance and also finds if there is a significant difference of job performance when sex, age, and clinical experience. Correlational research design was utilized where 164 registered nurses were conveniently sampled from Ghana. The study utilized selfconstructed survey questionnaire was for continuous professional development and Six Dimension Scale of Nursing Performance (SDNS) developed by Schwirian, (1978) was adopted and modified to measure the job performances of nurses. The statistical treatments used were Pearson Correlation, T-Test, and ANOVA to address the research questions. The study showed that there was a moderate positive significant relationship between continuing professional development and job. There was no significant difference in job performance when age, sex, and clinical experience were considered. Healthcare administrators should encourage and advocate for the participation of nurses in continuous learning to improve nurses their knowledge and skills on nurses. Institution policies should be properly aligned to help nurses in the participation of professional roles. Further research should explore other variables in relations to continuous professional development to improve the job performance of nurses.