This study aimed to investigate the mediating effect of the COVID-19 pandemic on the relationship between technology and organizational performance, using evidence from the Ghana banking industry. The study adopted a correlation and mediation research design, with 232 respondents conveniently sampled from eight indigenous Ghanaian Banks. The data were analyzed using correlation, regression, and mediation techniques. The results show that technology serves as a catalyst for improving organizational performance and alleviating the negative effects of COVID-19 on organizational performance. The findings also revealed that the COVID-19 pandemic highly mediates technology and organizational performance with a significant positive relationship between technology and COVID-19 pandemic; technology and organizational performance. Additionally, there is a significant positive high relationship between COVID-19 pandemic and organizational performance, with technology and COVID-19 pandemic predicting organizational performance. The COVID-19 pandemic moderately mediates organizational performance. Banks in Ghana need to secure technological solutions to remain competitive in this era of stiff competition and disasters to ensure customer satisfaction, optimize costs, remain profitable, and, above all, increase shareholder wealth. Keywords: COVID-19 pandemic, technology, organizational performance, Ghana, banking industry