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Article
Efficacy and Safety of Topical Selamectin to Eradicate Pinworm (Syphacia spp.) Infections in Rats (Rattus norvegicus) and Mice (Mus musculus)
Journal of the American Association for Laboratory Animal Science (2006)
  • William Allen Hill, University of Tennessee, Knoxville
  • Mildred Montgomery Randolph, University of Tennessee Health Science Center
  • Sharon Jean Lokey, University of Tennessee Health Science Center
  • Ernestine Hayes, University of Tennessee Health Science Center
  • Kelli Lynn Boyd
  • Timothy David Mandrell, University of Tennessee Health Science Center
Abstract
We evaluated the efficacy and safety of topical selamectin, a novel avermectin, in eliminating naturally acquired Syphacia muris infections in rats and S. obvelata infections in mice. S. muris-positive rats were assigned randomly to 4 groups: selamectin (0.6 mg/kg), selamectin (6.0 mg/kg), fenbendazole-medicated (150 ppm) chow, and untreated. S. obvelata-positive mice were allocated into 4 groups similar to those for rats. Animals not exposed to pinworm-contaminated bedding were designated as negative controls. Treatment success was assessed weekly by anal tape impressions and by necropsy examinations at the end of week 9. Evaluations of intestinal contents at necropsy revealed that, although safe, topical selamectin was 100% ineffective in eliminating Syphacia spp. infections in rats and mice. Treatment with fenbendazole-medicated chow resulted in negative anal tape impressions beginning at week 2 in rats and week 1 in mice. Negative anal tape impressions in fenbendazole-treated animals were confirmed by negative intestinal content evaluations. Of the 2 treatments evaluated, fenbendazole-medicated chow remains an effective and practical method to eliminate pinworm infections in mice and rats.
Publication Date
May, 2006
Citation Information
William Allen Hill, Mildred Montgomery Randolph, Sharon Jean Lokey, Ernestine Hayes, et al.. "Efficacy and Safety of Topical Selamectin to Eradicate Pinworm (Syphacia spp.) Infections in Rats (Rattus norvegicus) and Mice (Mus musculus)" Journal of the American Association for Laboratory Animal Science Vol. 45 Iss. 3 (2006)
Available at: http://works.bepress.com/william_hill/2/