Sciatic nerve neuropathy due to infiltrating of a high grade B-cell lymphoma is a very rare situation and has not often been reported. We report a case with a previous history of indolent lymphoma who presented with isolated sciatic nerve neuropathy and was found to have diffuse large B cell lymphoma involving the sciatic nerve. Although the current case is not a primary sciatic nerve lymphoma given the systematic involvement shown on MRI and PET/CT scan, the case represents a neurolymphomatosis of the sciatic nerve given the direct invasion of the lymphoma cells into the sciatic nerve. Due to the rarity of this condition, we subsequently reviewed related literatures.
He, W., Wang, W., Gustas, C., Malysz, J., & Kaur, D. (2016). Isolated sciatic neuropathy as an initial manifestation of a high grade B-cell lymphoma: A case report and literature review. Clinical Neurology And Neurosurgery, 149147-153. doi:10.1016/j.clineuro.2016.07.029