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True Aneurysms of the Posterior Communicating Artery: a Systematic review and Meta-Analysis of Individual Patient data.
World Neurosurg
  • Wenzhuan He, Lehigh Valley Health Network
  • Chirag D Gandhi, MD
  • John Quinn
  • Reza J Karimi, MD
  • Charles J Prestigiacomo, MD
Publication/Presentation Date

OBJECTIVE: To review and analyze systematically the reported cases of "true" posterior communicating artery (PCoA) aneurysm.

METHODS: A retrospective review of the published literature was performed, and a meta-analysis of individual patient data was conducted.

RESULTS: Pooled data showed that "true" PCoA aneurysms represent about 1.3% (95% confidence interval [CI] 0.8%, 1.7%) of all intracranial aneurysms and 6.8% (95% CI 4.3%, 9.2%) of all PCoA aneurysms. Mean patient age was 53.5 years (53.5 years ± 15.4), and age range was 23-79 years. Of the 49 patients reported in the literature, 44 (89.8%) were reported as ruptured, and 4 (10.2%) were reported as unruptured. There were no significant differences in ruptured status between age (P = 0.321), left vs right aneurysm (P = 0.537), and shape of aneurysm (P = 0.408). No significant differences in complication rates were found between rupture status (P = 0.27), and operative modalities (P = 0.878). The mean ages of patients who had no complications and patients who had complications were 53 years (53 years ± 2.59) vs 53.2 years (53.2 years ± 5.02) (P = 0.972).

CONCLUSIONS: "True" PCoA aneurysms represent about 1.3% of all intracranial aneurysms and 6.8% of all PCoA aneurysms. They are more prone to rupture compared with their counterpart junctional aneurysms. When surgical management is indicated, a good understanding of the location and configuration of the aneurysm neck before surgical treatment is critical in the successful treatment of these lesions.

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Citation Information

HE, W; et al. True aneurysms of the posterior communicating artery: a systematic review and meta-analysis of individual patient data. World Neurosurgery. United States, 75, 1, 64-72, Jan. 2011. ISSN: 1878-8769.