Skip to main content
Article
Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus
University of Massachusetts Medical School Faculty Publications
  • Jinyan Liu, Beth Israel Deaconess Medical Center
  • Wenjun Li, University of Massachusetts Medical School
  • Dan H. Barouch, Beth Israel Deaconess Medical Center, Boston
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Publication Date
9-2-2016
Document Type
Article
Abstract
HIV-1-specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naive hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.
Rights and Permissions
Citation: Science. 2016 Sep 2;353(6303):1045-1049. Epub 2016 Aug 18. Link to article on publisher's site
Comments

Full list of authors omitted for brevity. For full list see article.

Related Resources
Link to Article in PubMed
PubMed ID
27540005
Citation Information
Jinyan Liu, Wenjun Li and Dan H. Barouch. "Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus" Vol. 353 Iss. 6303 (2016) ISSN: 0036-8075 (Linking)
Available at: http://works.bepress.com/wenjun_li/157/