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Nanoroughened Surfaces for Efficient Capture of Circulating Tumor Cells without Using Capture Antibodies
ACS Nano (2012)
  • Weiqiang Chen, University of Michigan - Ann Arbor
  • Shinuo Weng, University of Michigan - Ann Arbor
  • Feng Zhang
  • Steven Allen, University of Michigan - Ann Arbor
  • Xiang Li, University of Michigan - Ann Arbor
  • Liwei Bao, University of Michigan - Ann Arbor
  • Raymond H. W. Lam, City University of Hong Kong
  • Jill A. Macoska, University of Michigan - Ann Arbor
  • Sofia D. Merajver, University of Michigan - Ann Arbor
  • Jianping Fu, University of Michigan - Ann Arbor
Abstract
Circulating tumor cells (CTCs) detached from both primary and metastatic lesions represent a potential alternative to invasive biopsies as a source of tumor tissue for the detection, characterization and monitoring of cancers. Here we report a simple yet effective strategy for capturing CTCs without using capture antibodies. Our method uniquely utilized the differential adhesion preference of cancer cells to nanorough surfaces when compared to normal blood cells and thus did not depend on their physical size or surface protein expression, a significant advantage as compared to other existing CTC capture techniques.
Publication Date
Fall November 29, 2012
Citation Information
Weiqiang Chen, Shinuo Weng, Feng Zhang, Steven Allen, et al.. "Nanoroughened Surfaces for Efficient Capture of Circulating Tumor Cells without Using Capture Antibodies" ACS Nano Vol. 7 Iss. 1 (2012)
Available at: http://works.bepress.com/weiqiang_chen/9/