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Article
Microfabricated Nanotopological Surfaces for Study of Adhesion-Dependent Cell Mechanosensitivity
Small (2013)
  • Weiqiang Chen, University of Michigan - Ann Arbor
  • Yubing Sun, University of Michigan - Ann Arbor
  • Jianping Fu, University of Michigan - Ann Arbor
Abstract
Cells exhibit high sensitivity and diverse responses to the intrinsic nanotopography of the extracellular matrix through their nanoscale cellular sensing machinery. A simple microfabrication method for precise control and spatial patterning of the local nanoroughness on glass surfaces by using photolithography and reactive ion etching is reported. It is demonstrated that local nanoroughness as a biophysical cue could regulate a diverse array of NIH/3T3 fi broblast behaviors, including cell morphology, adhesion, proliferation, migration, and cytoskeleton contractility. The capability to control and further predict cellular responses to nanoroughness might suggest novel methods for developing biomaterials mimicking nanotopographic structures in vivo for functional tissue engineering.
Publication Date
Winter January 1, 2013
Citation Information
Weiqiang Chen, Yubing Sun and Jianping Fu. "Microfabricated Nanotopological Surfaces for Study of Adhesion-Dependent Cell Mechanosensitivity" Small Vol. 9 Iss. 1 (2013)
Available at: http://works.bepress.com/weiqiang_chen/11/