This paper initiated an investigation on the following question: Suppose that a smooth 4 -manifold does not admit any smooth circle actions. Does there exist a constant C>0 such that the manifold supports no smooth Zp -actions of prime order for p>C ? We gave affirmative results to this question for the case of holomorphic and symplectic actions, with an interesting finding that the constant C in the holomorphic case is topological in nature, while in the symplectic case it involves also the smooth structure of the manifold.